The E Street Band has been rock musician Bruce Springsteen's primary backing band since 1972.

The band has also recorded (both individually and as a band) with a wide range of other artists including Bob Dylan, Meat Loaf, Bonnie Tyler, Air Supply, Dire Straits, David Bowie, Peter Gabriel, Stevie Nicks, Tom Morello, Sting, Ian Hunter, Ringo Starr, Ray Davies, Ronnie Spector, Gary U.S. Bonds, Darlene Love, Southside Johnny, The Grateful Dead, Santana, Lucinda Williams, Steve Earle, Emmylou Harris, Tracy Chapman, Lady Gaga, and Aretha Franklin.

When not working with Springsteen, members of the band have recorded solo material and have pursued successful careers as session musicians, record producers, songwriters, actors, and other roles in entertainment. The most well known in their separate careers are Max Weinberg, who has led his own band, first on Late Night with Conan O'Brien and then on The Tonight Show with Conan O'Brien, from 1993 - 2010, and Steven Van Zandt, who starred as Silvio Dante in the television series The Sopranos from 1999 to 2007.