After a disappointing end to their magnificent playoff run in 2006, the Mavericks sought retribution in the new season. After a rocky 0-4 start, the Mavericks then went on an historic run and posted a 52-5 record over their next 57 games. They finished out the regular season with a record of 67-15, good enough to be tied for 6th place all-time, 1st in the league and the #1 seed in the Western Conference playoffs.

Dirk Nowitzki had a dominant season, further cementing his place as one of the game's elite players and was named MVP.

Josh Howard was named to the all-star team.

However, the 8th seeded Golden State Warriors systematically dismantled the Mavericks in the first round of the playoffs by exploiting matchups and preying on Dirk Nowitzki's weaknesses.

Dirk Nowitzki and his 1st place Mavericks were defeated in 6 games by the 8th seeded Warriors to give way to the biggest upset in NBA history, although former NBA champion and All-Star legend Bill Russell stated in his NBA.com blog that he didn't consider it to be an upset, since Golden State was 3-0 vs. the Mavericks in the regular season. The Mavs were exposed defensively.